Comparative 3D QSAR study on β1-, β2-, and β3-adrenoceptor agonists
نویسندگان
چکیده
منابع مشابه
Investigation of adrenoceptor genes (β2 & β3) in women with polycystic ovary syndrome
Background: Genetic polymorphism is responsible for variations and individual differences. Polymorphism is a major factor of complex diseases with unknown etiology and cancer. Inconsistency in the symptoms of polycystic ovary syndrome (monthly disorder, hirsutism, obesity, diabetes, infertility) is one of the major pathological complications of this syndrome. The present study was conducted to ...
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The aim of this study was to compare the binding profile of a range of β2-adrenoceptor (β2-AR) agonists and antagonists in human lung tissue. Radioligand saturation and competition binding experiments were performed by filtration with a β2-AR antagonist ([H]propranolol) or agonist ([H]vilanterol) radioligand and membrane fragments generated from lung parenchyma in the presence of 100 μM guanosi...
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The clinical success of mirabegron as the first β3-adrenoceptor (AR) agonist for treatment of the overactive bladder (OAB) syndrome, has resulted in substantial interest in its site and mechanism of action. Even if the adrenergic innervation of the bladder and urethra has been well studied, the location(s) of β3-ARs in different structures within the bladder wall and urethra, and the mode(s) of...
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Copyright © 2017 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A Clinician’s Perspective on the Mechanism of β3...
متن کاملCharacterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas).
Complimentary DNAs for three beta-adrenergic receptors (βARs) were isolated and characterised in the fathead minnow. The encoded proteins of 402 (β(1)AR), 397 (β(2)AR) and 434 (β(3)AR) amino acids were homologous to other vertebrate βARs, and displayed the characteristic seven transmembrane helices of G Protein-coupled receptors. Motifs and amino acids shown to be important for ligand binding w...
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2009
ISSN: 1054-2523,1554-8120
DOI: 10.1007/s00044-009-9257-x